Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells
                    
                        
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                    چکیده
منابع مشابه
Interleukin-6 expression and regulation in rat enteric glial cells.
As yet, little is known about the function of the glia of the enteric nervous system (ENS), particularly in an immune-stimulated environment. This prompted us to study the potential of cultured enteroglial cells for cytokine synthesis and secretion. Jejunal myenteric plexus preparations from adult rats were enzymatically dissociated, and enteroglial cells were purified by complement-mediated cy...
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Increased amounts of reactive oxygen species (ROS) induce apoptosis in mammalian cells. PUMA (P53 up-regulated modulator of apoptosis), a mitochondrial proapoptotic BH3-only protein, induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. However, the molecular basis of PUMA-induced apoptosis is largely not understood. Using a combination of biophysical and biochemical method...
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OBJECTIVES We recently found low level of tumor suppressor programmed cell death 4 (PDCD4) associated with reduced atherosclerotic plaque area (unpublished). We investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells. METHODS AND RESULTS En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in ...
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Under prolonged diabetic conditions, HbA1c is produced from normal hemoglobin (HbA0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (metHb). Here we are reporting that the non-enzymatic reaction between fructose and metHb (metHb fructation) induces significant changes in the gl...
متن کاملInterstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease.
BACKGROUND Colonic diverticular disease (diverticulosis) is a common disorder in Western countries. Although its pathogenesis is probably multifactorial, motor abnormalities of the large bowel are thought to play an important role. However, little is known about the basic mechanism that may underlie abnormal colon motility in diverticulosis. AIMS To investigate the interstitial cells of Cajal...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2017
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2017.08.038